Outcomes of surgical treatment of advanced gastrointestinal stromal tumors

Abstract

Targeted therapy of imatinib is a standard treatment of patients with metastatic gastrointestinal stromal tumors (GIST). The role of surgical approach in treatment of patients with disseminated GIST is remaining the most important and controversial issues. The retrospective analysis of the treatment of 140 patients with disseminated GIST to assess the efficacy of surgical treatment was carried out. Surgical treatments in combination with targeted therapy were performed in 98 patients and 42 patients were treated using only tyrosine kinase inhibitors.Comparative analysis showed the statistically significant improvement of remote results in the group of patients undergoing surgical operations associated with the effect of therapy using tyrosine kinase inhibitors. Cytoreductive surgery in patients with diffuse progression on imatinib therapy does not improve survival rates.

Keywords

• gastrointestinal stromal tumors
• gastrointestinal stromal tumors of the gastrointestinal tract
• imatinib
• surgical treatment