Nature Communications (May 2019)
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation
- Sibylle Cocciardi,
- Anna Dolnik,
- Silke Kapp-Schwoerer,
- Frank G. Rücker,
- Susanne Lux,
- Tamara J. Blätte,
- Sabrina Skambraks,
- Jan Krönke,
- Florian H. Heidel,
- Tina M. Schnöder,
- Andrea Corbacioglu,
- Verena I. Gaidzik,
- Peter Paschka,
- Veronica Teleanu,
- Gudrun Göhring,
- Felicitas Thol,
- Michael Heuser,
- Arnold Ganser,
- Daniela Weber,
- Eric Sträng,
- Hans A. Kestler,
- Hartmut Döhner,
- Lars Bullinger,
- Konstanze Döhner
Affiliations
- Sibylle Cocciardi
- Department of Internal Medicine III, University Hospital of Ulm
- Anna Dolnik
- Department of Internal Medicine III, University Hospital of Ulm
- Silke Kapp-Schwoerer
- Department of Internal Medicine III, University Hospital of Ulm
- Frank G. Rücker
- Department of Internal Medicine III, University Hospital of Ulm
- Susanne Lux
- Department of Internal Medicine III, University Hospital of Ulm
- Tamara J. Blätte
- Department of Internal Medicine III, University Hospital of Ulm
- Sabrina Skambraks
- Department of Internal Medicine III, University Hospital of Ulm
- Jan Krönke
- Department of Internal Medicine III, University Hospital of Ulm
- Florian H. Heidel
- Department of Internal Medicine II, Hematology and Oncology, Friedrich-Schiller-University Medical Center
- Tina M. Schnöder
- Department of Internal Medicine II, Hematology and Oncology, Friedrich-Schiller-University Medical Center
- Andrea Corbacioglu
- Department of Internal Medicine III, University Hospital of Ulm
- Verena I. Gaidzik
- Department of Internal Medicine III, University Hospital of Ulm
- Peter Paschka
- Department of Internal Medicine III, University Hospital of Ulm
- Veronica Teleanu
- Department of Internal Medicine III, University Hospital of Ulm
- Gudrun Göhring
- Institute of Cell & Molecular Pathology, Hannover Medical School
- Felicitas Thol
- Department of Haematology, Haemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School
- Michael Heuser
- Department of Haematology, Haemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School
- Arnold Ganser
- Department of Haematology, Haemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School
- Daniela Weber
- Department of Internal Medicine III, University Hospital of Ulm
- Eric Sträng
- Institute of Medical Systems Biology, Ulm University
- Hans A. Kestler
- Institute of Medical Systems Biology, Ulm University
- Hartmut Döhner
- Department of Internal Medicine III, University Hospital of Ulm
- Lars Bullinger
- Department of Internal Medicine III, University Hospital of Ulm
- Konstanze Döhner
- Department of Internal Medicine III, University Hospital of Ulm
- DOI
- https://doi.org/10.1038/s41467-019-09745-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
NPM1 gene mutation is a founding event in acute myeloid leukaemia. Here, the authors find that at relapse, some patients lose the NPM1 mutation and show distinct mutational and gene expression patterns, highlighting a potential route for relapse.
