Miniaturized peptidomimetics and nano-vesiculation in endothelin types through probable nano-disk formation and structure property relationships of endothelins’ fragments

Abstract

The present study deals with the molecular modeling studies of the endothelins (ETs), a multi-functional 21 amino acid (AA) peptides, with sub-types ET-I, II, and III to find the structure property relationship (SPR) of different fragments naturally derived from the cyclic body part of the ETs’ structures together with the structurally similar and common tail sequence (AA 16–21) utilization of the ETs and the dissimilar sarafotoxin-6b (SRT-6b) hexapeptide chain tail, as well as their SPR comparisons to find peptide-based leads as comparable to the ETs, especially ET-I. Approach to plausible vesiculation of the ETs and the involved process as a suggested mechanism is also discussed.

Keywords

• endothelins
• sarafotoxin-6b
• structure property relationships
• compartmentalization
• miniaturized peptide
• peptidomimetics
• vesiculation