Bioinspired Andrias davidianus-Derived wound dressings for localized drug-elution

Xiang Liu; Xiang Mao; Guo Ye; Menghong Wang; Ke Xue; Yan Zhang; Hongmei Zhang; Xiaoqiao Ning; Man Zhao; Jinlin Song; Yu Shrike Zhang; Ximu Zhang

Bioactive Materials (Sep 2022)

Bioinspired Andrias davidianus-Derived wound dressings for localized drug-elution

Xiang Liu,
Xiang Mao,
Guo Ye,
Menghong Wang,
Ke Xue,
Yan Zhang,
Hongmei Zhang,
Xiaoqiao Ning,
Man Zhao,
Jinlin Song,
Yu Shrike Zhang,
Ximu Zhang

Affiliations

Xiang Liu: Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing, 401174, China
Xiang Mao: State Key Laboratory of Ultrasound in Medicine and Engineering and Chongqing Key Laboratory of Biomedical Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China
Guo Ye: Department of Stomatology, The Third Affiliated Hospital, Chongqing Medical University, Chongqing, 401120, China
Menghong Wang: Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing, 401174, China
Ke Xue: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Rd, Shanghai, 200011, China; Department of Plastic and reconstructive surgery, Hainan Western Central Hospital, HaiNan, 571700, China
Yan Zhang: Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing, 401174, China
Hongmei Zhang: Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing, 401174, China
Xiaoqiao Ning: Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing, 401174, China
Man Zhao: Department of Pharmacy, The 958th Hospital of PLA, Chongqing, 404100, China
Jinlin Song: Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing, 401174, China; Corresponding author.
Yu Shrike Zhang: Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA; Corresponding author.
Ximu Zhang: Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing, 401174, China; Corresponding author.

Journal volume & issue: Vol. 15
pp. 482 – 494

Abstract

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Local drug delivery has received increasing attention in recent years. However, the therapeutic efficacy of local delivery of drugs is still limited under certain scenarios, such as in the oral cavity or in wound beds after resection of tumors. In this study, we introduce a bioinspired adhesive hydrogel derived from the skin secretions of Andrias davidianus (SSAD) as a wound dressing for localized drug elution. The hydrogel was loaded with aminoguanidine or doxorubicin, and its controlled drug release and healing-promoting properties were verified in a diabetic rat palatal mucosal defect model and a C57BL/6 mouse melanoma-bearing model, respectively. The results showed that SSAD hydrogels with different pore sizes could release drugs in a controllable manner and accelerate wound healing. Transcriptome analyses of the palatal mucosa suggested that SSAD could significantly upregulate pathways linked to cell adhesion and extracellular matrix deposition and had the ability to recruit keratinocyte stem cells to defect sites. Taken together, these findings indicate that property-controllable SSAD hydrogels could be a promising biofunctional wound dressing for local drug delivery and promotion of wound healing.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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