Cellular imaging by targeted assembly of hot-spot SERS and photoacoustic nanoprobes using split-fluorescent protein scaffolds

Tuğba Köker; Nathalie Tang; Chao Tian; Wei Zhang; Xueding Wang; Richard Martel; Fabien Pinaud

doi:10.1038/s41467-018-03046-w

Nature Communications (Feb 2018)

Cellular imaging by targeted assembly of hot-spot SERS and photoacoustic nanoprobes using split-fluorescent protein scaffolds

Tuğba Köker,
Nathalie Tang,
Chao Tian,
Wei Zhang,
Xueding Wang,
Richard Martel,
Fabien Pinaud

Affiliations

Tuğba Köker: Department of Biological Sciences, University of Southern California
Nathalie Tang: Department of Chemistry, University of Montréal
Chao Tian: Department of Biomedical Engineering, University of Michigan
Wei Zhang: Department of Biomedical Engineering, University of Michigan
Xueding Wang: Department of Biomedical Engineering, University of Michigan
Richard Martel: Department of Chemistry, University of Montréal
Fabien Pinaud: Department of Biological Sciences, University of Southern California

DOI: https://doi.org/10.1038/s41467-018-03046-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Traditional methods for the assembly of plasmonic nanoparticles into photo-responsive probes suffer from multiple problems. Here the authors use split fluorescent protein fragments as molecular glue to form stable nanoclusters for surface enhanced Raman scattering and photoacoustic imaging in live cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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