THE TECHNOLOGY OF OBTAINING OF HEMOSTATIC GEL OF LAGODEN ON THE BASE OF CARBOPOL

Abstract

We are conducting a series of experiments for the development of technology of Lagoden hemostatic gel obtaining. We studied different bases for the gel obtaining. According to the results, carbopol was selected as a gelling agent. By studying the change in the rheological properties of the gel and technological basis, a series of experiments were done to determine the concentration of a gelling agent and a neutralizing agent. We worked on an optimal composition of the drug and a method for producing it in the technological process. Initially some substances like carbopol, sodium hydroxide, glycerin, purified water, and preservatives were used. Lagoden is a sodium salt trihydrate 3,16,18-trihydroxy-9,13-epoxilabdan-15-carboxylic acid. Lagoden is obtained by processing of Inebrin substance, which is obtained from a Lagochilus inebriansplant. Lagochilus inebrians has been used in folk medicine for a long time.The aim of the work was to develop technology of obtaining of the soft drug form of Lagoden.Methods. Chemical reactions, me-thods of soft drug forms obtaining were used in the study.Results. Influence of different gel components on Lagoden gel were tested through various experiments. After studying of gel characteristics which on the basis of carbopol-934 its alternative concentration for the formation of optimal gelwas defined. The experiments determined that the carbopol gel retained its physical state in the range of 5.5 <pH <8.2. To neutralize 1.000 g of dry carbopol 0.42 g of dry sodium hydroxide or 0.80 g of triethylamine or 0.68 g of ethanolamine are needed.Conclusions. For the first time a method of Lagoden gel obtaining was designed which stops haemorrhage. A technological process of taking/obtaining of semisolid drug form of the Lagoden was developed.

Keywords

• lagoden
• hemostatic facilities
• carbopol-934
• makrogel
• electrostatic push
• hydrophilic base