Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects

• Zehao Jing,
• Wanqiong Yuan,
• Jiedong Wang,
• Renhua Ni,
• Yu Qin,
• Zhinan Mao,
• Feng Wei,
• Chunli Song,
• Yufeng Zheng,
• Hong Cai,
• Zhongjun Liu

Affiliations

Zehao Jing

Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, People's Republic of China; Beijing Key Laboratory of Spinal Disease Research, Beijing, 100191, People's Republic of China

Wanqiong Yuan

Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, People's Republic of China; Beijing Key Laboratory of Spinal Disease Research, Beijing, 100191, People's Republic of China

Jiedong Wang

Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, People's Republic of China; Beijing Key Laboratory of Spinal Disease Research, Beijing, 100191, People's Republic of China

Renhua Ni

Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, People's Republic of China; Beijing Key Laboratory of Spinal Disease Research, Beijing, 100191, People's Republic of China

Yu Qin

School of Materials Science and Engineering, Peking University, Beijing, 100871, People's Republic of China

Zhinan Mao

School of Materials Science and Engineering, Peking University, Beijing, 100871, People's Republic of China

Feng Wei

Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, People's Republic of China; Beijing Key Laboratory of Spinal Disease Research, Beijing, 100191, People's Republic of China

Chunli Song

Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, People's Republic of China

Yufeng Zheng

School of Materials Science and Engineering, Peking University, Beijing, 100871, People's Republic of China; Corresponding author. School of Materials Science and Engineering, Peking University, Beijing, 100871, People's Republic of China.

Hong Cai

Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, People's Republic of China; Corresponding author. Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China.

Zhongjun Liu

Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, People's Republic of China; Beijing Key Laboratory of Spinal Disease Research, Beijing, 100191, People's Republic of China; Corresponding author. Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China.