Nature Communications (Mar 2020)
Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma
- Richa Bajpai,
- Aditi Sharma,
- Abhinav Achreja,
- Claudia L. Edgar,
- Changyong Wei,
- Arusha A. Siddiqa,
- Vikas A. Gupta,
- Shannon M. Matulis,
- Samuel K. McBrayer,
- Anjali Mittal,
- Manali Rupji,
- Benjamin G. Barwick,
- Sagar Lonial,
- Ajay K. Nooka,
- Lawrence H. Boise,
- Deepak Nagrath,
- Mala Shanmugam
Affiliations
- Richa Bajpai
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Aditi Sharma
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Abhinav Achreja
- Department of Biomedical Engineering, University of Michigan
- Claudia L. Edgar
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Changyong Wei
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Arusha A. Siddiqa
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Vikas A. Gupta
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Shannon M. Matulis
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Samuel K. McBrayer
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- Anjali Mittal
- Biointerfaces Institute, University of Michigan
- Manali Rupji
- Department of Biostatistics and Bioinformatics Shared Resource, Winship Cancer Institute, Emory University
- Benjamin G. Barwick
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Sagar Lonial
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Ajay K. Nooka
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Lawrence H. Boise
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- Deepak Nagrath
- Department of Biomedical Engineering, University of Michigan
- Mala Shanmugam
- Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University
- DOI
- https://doi.org/10.1038/s41467-020-15051-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with IACS-010759 or CII with TTFA increase sensitivity.
