A qualitative investigation of RANKL, RANK and OPG in a rat model of transient ankylosis

Abstract

Introduction: Previous studies have found ankylosis occurs as a part of the inflammatory process of aseptic root resorption initiated in a rat model.1 The physiologic mechanisms behind the development of dentoalveolar ankylosis and healing response are still unclear. While receptor activator of nuclear factor-κβ ligand (RANKL), receptor activator of nuclear factor-κβ (RANK) and osteoprotegerin (OPG) have gained momentum in the understanding of resorption, no study to date has investigated their role in dentoalveolar ankylosis.