Nature Communications (Mar 2022)
Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox
- Zhen-Xing Wang,
- Zhong-Wei Luo,
- Fu-Xing-Zi Li,
- Jia Cao,
- Shan-Shan Rao,
- Yi-Wei Liu,
- Yi-Yi Wang,
- Guo-Qiang Zhu,
- Jiang-Shan Gong,
- Jing-Tao Zou,
- Qiang Wang,
- Yi-Juan Tan,
- Yan Zhang,
- Yin Hu,
- You-You Li,
- Hao Yin,
- Xiao-Kai Wang,
- Ze-Hui He,
- Lu Ren,
- Zheng-Zhao Liu,
- Xiong-Ke Hu,
- Ling-Qing Yuan,
- Ran Xu,
- Chun-Yuan Chen,
- Hui Xie
Affiliations
- Zhen-Xing Wang
- Department of Orthopedics, Xiangya Hospital, Central South University
- Zhong-Wei Luo
- Department of Orthopedics, Xiangya Hospital, Central South University
- Fu-Xing-Zi Li
- The Second Xiangya Hospital, Central South University
- Jia Cao
- Department of Orthopedics, Xiangya Hospital, Central South University
- Shan-Shan Rao
- Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University
- Yi-Wei Liu
- Department of Orthopedics, Xiangya Hospital, Central South University
- Yi-Yi Wang
- Department of Orthopedics, Xiangya Hospital, Central South University
- Guo-Qiang Zhu
- Department of Orthopedics, Xiangya Hospital, Central South University
- Jiang-Shan Gong
- Department of Orthopedics, Xiangya Hospital, Central South University
- Jing-Tao Zou
- Department of Orthopedics, Xiangya Hospital, Central South University
- Qiang Wang
- Department of Laboratory Medicine, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou
- Yi-Juan Tan
- Department of Orthopedics, Xiangya Hospital, Central South University
- Yan Zhang
- Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University
- Yin Hu
- Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University
- You-You Li
- Department of Orthopedics, Xiangya Hospital, Central South University
- Hao Yin
- Department of Orthopedics, Xiangya Hospital, Central South University
- Xiao-Kai Wang
- Department of Emergency Medicine, Xiangya Hospital, Central South University
- Ze-Hui He
- Department of Orthopedics, Xiangya Hospital, Central South University
- Lu Ren
- The Second Xiangya Hospital, Central South University
- Zheng-Zhao Liu
- Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University
- Xiong-Ke Hu
- Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University
- Ling-Qing Yuan
- The Second Xiangya Hospital, Central South University
- Ran Xu
- The Second Xiangya Hospital, Central South University
- Chun-Yuan Chen
- Department of Orthopedics, Xiangya Hospital, Central South University
- Hui Xie
- Department of Orthopedics, Xiangya Hospital, Central South University
- DOI
- https://doi.org/10.1038/s41467-022-29191-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
This study uncovers the role of extracellular vesicles from bone matrix as a messenger in the development of osteoporosis and vascular calcification (calcification paradox) during skeletal aging and menopause by transferring miR-483-5p and miR-2861.
