Clinical and hematological profile of patients with severe aplastic anaemia

Abstract

Clinical and heamatologic profile of twenty six patients with severe aplastic anemia are described. This disease is common in second decade of life and in males. Common presenting symptoms were bleeding diathesis, fever and weakness. Drug history was positive in fourteen cases, the common drugs incriminated were indigenous drugs and chloramphenical. Apart from anemia being present in all the cases, eleven patients had hepatomegaly, five had splenomegaly, three had congestive cardiac failure and two had lymphadenopathy. Experience with corticosteroids, Anabolic steroids and lithium at our centre shows poor results. Bone marrow transplantation may be the treatment of choice.

Keywords

• aplastic anemia
• profile
• diseases