Nature Communications (2017-12-01)

Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

  • Youngzee Song,
  • Huihao Zhou,
  • My-Nuong Vo,
  • Yi Shi,
  • Mir Hussain Nawaz,
  • Oscar Vargas-Rodriguez,
  • Jolene K. Diedrich,
  • John R. Yates,
  • Shuji Kishi,
  • Karin Musier-Forsyth,
  • Paul Schimmel

Journal volume & issue
Vol. 8, no. 1
pp. 1 – 8


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Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.