Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Youngzee Song; Huihao Zhou; My-Nuong Vo; Yi Shi; Mir Hussain Nawaz; Oscar Vargas-Rodriguez; Jolene K. Diedrich; John R. Yates; Shuji Kishi; Karin Musier-Forsyth; Paul Schimmel

doi:10.1038/s41467-017-02201-z

Nature Communications (Dec 2017)

Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Youngzee Song,
Huihao Zhou,
My-Nuong Vo,
Yi Shi,
Mir Hussain Nawaz,
Oscar Vargas-Rodriguez,
Jolene K. Diedrich,
John R. Yates,
Shuji Kishi,
Karin Musier-Forsyth,
Paul Schimmel

Affiliations

Youngzee Song: The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute
Huihao Zhou: The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute
My-Nuong Vo: The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute
Yi Shi: The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute
Mir Hussain Nawaz: The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute
Oscar Vargas-Rodriguez: Department of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University
Jolene K. Diedrich: Department of Molecular Medicine, The Scripps Research Institute
John R. Yates: Department of Molecular Medicine, The Scripps Research Institute
Shuji Kishi: The Scripps Laboratories for tRNA Synthetase Research and Department of Molecular Medicine, The Scripps Research Institute
Karin Musier-Forsyth: Department of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University
Paul Schimmel: The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute

DOI: https://doi.org/10.1038/s41467-017-02201-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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