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Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Nature Communications. 2017;8(1):1-8 DOI 10.1038/s41467-017-02201-z

 

Journal Homepage

Journal Title: Nature Communications

ISSN: 2041-1723 (Online)

Publisher: Nature Publishing Group

LCC Subject Category: Science

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS


Youngzee Song (The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute)

Huihao Zhou (The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute)

My-Nuong Vo (The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute)

Yi Shi (The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute)

Mir Hussain Nawaz (The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute)

Oscar Vargas-Rodriguez (Department of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University)

Jolene K. Diedrich (Department of Molecular Medicine, The Scripps Research Institute)

John R. Yates (Department of Molecular Medicine, The Scripps Research Institute)

Shuji Kishi (The Scripps Laboratories for tRNA Synthetase Research and Department of Molecular Medicine, The Scripps Research Institute)

Karin Musier-Forsyth (Department of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University)

Paul Schimmel (The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute)

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 28 weeks

 

Abstract | Full Text

Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.