Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release
Tran Dinh Thang,
Ping-Chung Kuo,
Tsong-Long Hwang,
Mei-Lin Yang,
Nguyen Thi Bich Ngoc,
Tran Thi Ngoc Han,
Chi-Wen Lin,
Tian-Shung Wu
Affiliations
Tran Dinh Thang
Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam
Ping-Chung Kuo
Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
Tsong-Long Hwang
Graduate Institute of Natural Products and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Mei-Lin Yang
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan
Nguyen Thi Bich Ngoc
Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam
Tran Thi Ngoc Han
Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam
Chi-Wen Lin
Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
Tian-Shung Wu
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan
The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.
