Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

Tran Dinh Thang; Ping-Chung Kuo; Tsong-Long Hwang; Mei-Lin Yang; Nguyen Thi Bich Ngoc; Tran Thi Ngoc Han; Chi-Wen Lin; Tian-Shung Wu

doi:10.3390/molecules181114285

Molecules (Nov 2013)

Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

Tran Dinh Thang,
Ping-Chung Kuo,
Tsong-Long Hwang,
Mei-Lin Yang,
Nguyen Thi Bich Ngoc,
Tran Thi Ngoc Han,
Chi-Wen Lin,
Tian-Shung Wu

Affiliations

Tran Dinh Thang: Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam
Ping-Chung Kuo: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
Tsong-Long Hwang: Graduate Institute of Natural Products and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Mei-Lin Yang: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan
Nguyen Thi Bich Ngoc: Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam
Tran Thi Ngoc Han: Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam
Chi-Wen Lin: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
Tian-Shung Wu: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan

DOI: https://doi.org/10.3390/molecules181114285
Journal volume & issue: Vol. 18, no. 11
pp. 14285 – 14292

Abstract

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The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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