Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

Naoki Itokawa; Motohiko Oshima; Shuhei Koide; Naoya Takayama; Wakako Kuribayashi; Yaeko Nakajima-Takagi; Kazumasa Aoyama; Satoshi Yamazaki; Kiyoshi Yamaguchi; Yoichi Furukawa; Koji Eto; Atsushi Iwama

doi:10.1038/s41467-022-30440-2

Nature Communications (May 2022)

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

Naoki Itokawa,
Motohiko Oshima,
Shuhei Koide,
Naoya Takayama,
Wakako Kuribayashi,
Yaeko Nakajima-Takagi,
Kazumasa Aoyama,
Satoshi Yamazaki,
Kiyoshi Yamaguchi,
Yoichi Furukawa,
Koji Eto,
Atsushi Iwama

Affiliations

Naoki Itokawa: Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University
Motohiko Oshima: Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo
Shuhei Koide: Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo
Naoya Takayama: Department of Regenerative Medicine, Chiba University Graduate School of Medicine
Wakako Kuribayashi: Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University
Yaeko Nakajima-Takagi: Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo
Kazumasa Aoyama: Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University
Satoshi Yamazaki: Division of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo
Kiyoshi Yamaguchi: Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo
Yoichi Furukawa: Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo
Koji Eto: Department of Regenerative Medicine, Chiba University Graduate School of Medicine
Atsushi Iwama: Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University

DOI: https://doi.org/10.1038/s41467-022-30440-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Haematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here the authors demonstrate that differentially accessible regions in aged HSC chromatin are enriched for stress-responsive enhancers and act as an epigenetic hub to augment transcriptional responses of aged HSCs to external stimuli.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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