Nature Communications (Mar 2023)

Membrane-localized expression, production and assembly of Vibrio parahaemolyticus T3SS2 provides evidence for transertion

  • Karan Gautam Kaval,
  • Suneeta Chimalapati,
  • Sara D. Siegel,
  • Nalleli Garcia,
  • Jananee Jaishankar,
  • Ankur B. Dalia,
  • Kim Orth

DOI
https://doi.org/10.1038/s41467-023-36762-z
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 10

Abstract

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It has been proposed that bacterial membrane proteins may be produced via ‘transertion’, or concurrent transcription, translation and membrane insertion from membrane-associated genes. Here, Kaval et al. provide evidence supporting that Vibrio parahaemolyticus uses transertion to assemble a transmembrane complex (type III secretion system) used to inject virulence factors into host cells.