Anti-Inflammatory, Thrombolytic and Hair-Growth Promoting Activity of the <i>n</i>-Hexane Fraction of the Methanol Extract of <i>Leea indica</i> Leaves
Shahenur Alam Sakib,
Abu Montakim Tareq,
Ameerul Islam,
Ahmed Rakib,
Mohammad Nazmul Islam,
Mohammad Arafat Uddin,
Md. Masudur Rahman,
Veronique Seidel,
Talha Bin Emran
Affiliations
Shahenur Alam Sakib
Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh
Abu Montakim Tareq
Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh
Ameerul Islam
Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh
Ahmed Rakib
Department of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong 4331, Bangladesh
Mohammad Nazmul Islam
Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh
Mohammad Arafat Uddin
Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh
Md. Masudur Rahman
Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh
Veronique Seidel
Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK
Talha Bin Emran
Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh
The anti-inflammatory, thrombolytic, and hair growth-promoting activity of the n-hexane fraction from the methanol extract of Leea indica (NFLI) leaves was investigated. NFLI showed significant inhibition of hemolysis and protein denaturation, and exhibited a concentration-dependent thrombolytic activity. When applied topically to mice at concentrations of 10, 1, 0.1%, NFLI demonstrated a significant increase in average hair length (p L. indica towards PGD2 synthase (PDB ID: 2VD1), an enzyme that catalyses the isomerisation of prostaglandin H2 to PGD2 which is involved in hair loss. Phthalic acid, farnesol, n-tricosane, n-tetracosane, and n-heptacosane showed the best ligand efficiencies towards PGD2 synthase and their intermolecular interactions were visualised using BIOVIA Discovery Studio Visualizer. Our results indicate that L. indica could represent a promising natural alternative to tackle alopecia.
