The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

Wen Tian; Wen Tian; Shirley Y. Jiang; Xinguo Jiang; Xinguo Jiang; Rasa Tamosiuniene; Dongeon Kim; Torrey Guan; Siham Arsalane; Siham Arsalane; Shravani Pasupneti; Norbert F. Voelkel; Qizhi Tang; Mark R. Nicolls; Mark R. Nicolls

doi:10.3389/fimmu.2021.684657

Frontiers in Immunology (Aug 2021)

The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

Wen Tian,
Wen Tian,
Shirley Y. Jiang,
Xinguo Jiang,
Xinguo Jiang,
Rasa Tamosiuniene,
Dongeon Kim,
Torrey Guan,
Siham Arsalane,
Siham Arsalane,
Shravani Pasupneti,
Norbert F. Voelkel,
Qizhi Tang,
Mark R. Nicolls,
Mark R. Nicolls

Affiliations

Wen Tian: Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, United States
Wen Tian: Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States
Shirley Y. Jiang: Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States
Xinguo Jiang: Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, United States
Xinguo Jiang: Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States
Rasa Tamosiuniene: Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, United States
Dongeon Kim: Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States
Torrey Guan: Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, United States
Siham Arsalane: Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, United States
Siham Arsalane: Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States
Shravani Pasupneti: Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States
Norbert F. Voelkel: Department of Pulmonary Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands
Qizhi Tang: Department of Surgery, University of California San Francisco, San Francisco, CA, United States
Mark R. Nicolls: Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, United States
Mark R. Nicolls: Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States

DOI: https://doi.org/10.3389/fimmu.2021.684657
Journal volume & issue: Vol. 12

Abstract

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Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4+CD25highFOXP3+ Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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