A Wearable Integrated Microneedle Electrode Patch for Exercise Management in Diabetes
Boyu Zhu,
Lihang Zhu,
Xinru Li,
Ziyi Zhao,
Jiayi Cao,
Min Qi,
Zhigang Gao,
Lin Zhou,
Bin Su
Affiliations
Boyu Zhu
Institute of Analytical Chemistry, Department of Chemistry,
Zhejiang University, Hangzhou 310058, China.
Lihang Zhu
Department of Clinical Engineering, Second Affiliated Hospital, College of Medicine,
Zhejiang University, Hangzhou 310009, China.
Xinru Li
Institute of Analytical Chemistry, Department of Chemistry,
Zhejiang University, Hangzhou 310058, China.
Ziyi Zhao
Institute of Analytical Chemistry, Department of Chemistry,
Zhejiang University, Hangzhou 310058, China.
Jiayi Cao
Institute of Analytical Chemistry, Department of Chemistry,
Zhejiang University, Hangzhou 310058, China.
Min Qi
Institute of Analytical Chemistry, Department of Chemistry,
Zhejiang University, Hangzhou 310058, China.
Zhigang Gao
General Surgery Department, Children’s Hospital,
Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
Lin Zhou
Institute of Analytical Chemistry, Department of Chemistry,
Zhejiang University, Hangzhou 310058, China.
Bin Su
Institute of Analytical Chemistry, Department of Chemistry,
Zhejiang University, Hangzhou 310058, China.
Exercise is one of the preferred management strategies for diabetic patients, but the exercise mode including type, intensity, and duration time is quite different for each patient because of individual differences. Inadequate exercise has no effect on the blood glucose control, while overexercise may cause serious side effects, such as hypoglycemia and loss of blood glucose control. In this work, we report a closed-loop feedback mode for exercise management in diabetes. A minimally invasive, biocompatible microneedle electrode patch was fabricated and used for continuously monitoring the glucose in the interstitial fluid. Further, in conjunction with using a wireless electrochemical device, the glucose signals can be analyzed to output the potency of exercise and give advice on exercise management. A custom exercise given by this closed-loop feedback mode can reduce the used dose of insulin and avoid side effect during and after exercise. We believe that this work can provide a novel comprehensive guidance for diabetic patients.
