Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes

Anália Carmo; José G. Cunha-Vaz; Arsélio P. Carvalho; Maria Celeste Lopes

doi:10.1080/09629350020025764

Mediators of Inflammation (Jan 2000)

Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes

Anália Carmo,
José G. Cunha-Vaz,
Arsélio P. Carvalho,
Maria Celeste Lopes

Affiliations

Anália Carmo: Center of Ophthalmology, Institute for Biomedical Research on Light and Image, University of Coimbra, Coimbra, Portugal
José G. Cunha-Vaz: Center of Ophthalmology, Institute for Biomedical Research on Light and Image, University of Coimbra, Coimbra, Portugal
Arsélio P. Carvalho: Center for Neurosciences of Coimbra, Department of Zoology, University of Coimbra, Coimbra, Portugal
Maria Celeste Lopes: Center for Neurosciences of Coimbra, Department of Zoology, University of Coimbra, Coimbra, Portugal

DOI: https://doi.org/10.1080/09629350020025764
Journal volume & issue: Vol. 9, no. 5
pp. 243 – 248

Abstract

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Background: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1β (IL-1β ). This cytokine may be involved in the expression of the inducible isoform of the nitric oxide synthase (iNOS), with consequent synthesis of large amounts of NO and blood–retinal barrier (BRB) breakdown.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://www.hindawi.com/journals/mi/

About the journal