Saikosaponin A attenuates neural injury caused by ischemia/reperfusion

Abstract

Inflammation is involved in cerebral ischemia/reperfusion (I/R)-induced neurological damage. Saikosaponin A (SSa), extracted from Radix bupleuri, has been reported to exert anti-inflammatory effects. This article aimed to investigate whether SSa could ameliorate neuroinflammation mediated by ischemic stroke and the underlying mechanism.

Keywords

• ischemia
• neuroprotection
• stroke
• toll-like receptors
• hmgb1