Nature Communications (Aug 2019)
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
- Heming Wang,
- Jacqueline M. Lane,
- Samuel E. Jones,
- Hassan S. Dashti,
- Hanna M. Ollila,
- Andrew R. Wood,
- Vincent T. van Hees,
- Ben Brumpton,
- Bendik S. Winsvold,
- Katri Kantojärvi,
- Teemu Palviainen,
- Brian E. Cade,
- Tamar Sofer,
- Yanwei Song,
- Krunal Patel,
- Simon G. Anderson,
- David A. Bechtold,
- Jack Bowden,
- Richard Emsley,
- Simon D. Kyle,
- Max A. Little,
- Andrew S. Loudon,
- Frank A. J. L. Scheer,
- Shaun M. Purcell,
- Rebecca C. Richmond,
- Kai Spiegelhalder,
- Jessica Tyrrell,
- Xiaofeng Zhu,
- Christer Hublin,
- Jaakko A. Kaprio,
- Kati Kristiansson,
- Sonja Sulkava,
- Tiina Paunio,
- Kristian Hveem,
- Jonas B. Nielsen,
- Cristen J. Willer,
- John-Anker Zwart,
- Linn B. Strand,
- Timothy M. Frayling,
- David Ray,
- Deborah A. Lawlor,
- Martin K. Rutter,
- Michael N. Weedon,
- Susan Redline,
- Richa Saxena
Affiliations
- Heming Wang
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School
- Jacqueline M. Lane
- Program in Medical and Population Genetics, Broad Institute
- Samuel E. Jones
- Genetics of Complex Traits, University of Exeter Medical School
- Hassan S. Dashti
- Program in Medical and Population Genetics, Broad Institute
- Hanna M. Ollila
- Program in Medical and Population Genetics, Broad Institute
- Andrew R. Wood
- Genetics of Complex Traits, University of Exeter Medical School
- Vincent T. van Hees
- Netherlands eScience Center
- Ben Brumpton
- K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology
- Bendik S. Winsvold
- K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology
- Katri Kantojärvi
- Genomics and Biomarkers Unit, National Institute for Health and Welfare
- Teemu Palviainen
- Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki
- Brian E. Cade
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School
- Tamar Sofer
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School
- Yanwei Song
- Center for Genomic Medicine, Massachusetts General Hospital
- Krunal Patel
- Center for Genomic Medicine, Massachusetts General Hospital
- Simon G. Anderson
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester
- David A. Bechtold
- Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Jack Bowden
- MRC Integrative Epidemiology Unit at the University of Bristol
- Richard Emsley
- Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Simon D. Kyle
- Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford
- Max A. Little
- Department of Mathematics, Aston University
- Andrew S. Loudon
- Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Frank A. J. L. Scheer
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School
- Shaun M. Purcell
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School
- Rebecca C. Richmond
- MRC Integrative Epidemiology Unit at the University of Bristol
- Kai Spiegelhalder
- Clinic for Psychiatry and Psychotherapy, Medical Centre, University of Freiburg
- Jessica Tyrrell
- Genetics of Complex Traits, University of Exeter Medical School
- Xiaofeng Zhu
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Christer Hublin
- Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki
- Jaakko A. Kaprio
- Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki
- Kati Kristiansson
- Genomics and Biomarkers Unit, National Institute for Health and Welfare
- Sonja Sulkava
- Genomics and Biomarkers Unit, National Institute for Health and Welfare
- Tiina Paunio
- Genomics and Biomarkers Unit, National Institute for Health and Welfare
- Kristian Hveem
- K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology
- Jonas B. Nielsen
- Department of Internal Medicine, Division of Cardiology, University of Michigan
- Cristen J. Willer
- Department of Internal Medicine, Division of Cardiology, University of Michigan
- John-Anker Zwart
- Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo
- Linn B. Strand
- K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology
- Timothy M. Frayling
- Genetics of Complex Traits, University of Exeter Medical School
- David Ray
- NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital
- Deborah A. Lawlor
- MRC Integrative Epidemiology Unit at the University of Bristol
- Martin K. Rutter
- Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Michael N. Weedon
- Genetics of Complex Traits, University of Exeter Medical School
- Susan Redline
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School
- Richa Saxena
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-11456-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
A main symptom of chronic insufficient sleep is excessive daytime sleepiness. Here, Wang et al. report 42 genome-wide significant loci for self-reported daytime sleepiness in 452,071 individuals from the UK Biobank that cluster into two biological subtypes of either sleep propensity or sleep fragmentation.
