Nature Communications (Aug 2019)
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
- Elizabeth Spangenberg,
- Paul L. Severson,
- Lindsay A. Hohsfield,
- Joshua Crapser,
- Jiazhong Zhang,
- Elizabeth A. Burton,
- Ying Zhang,
- Wayne Spevak,
- Jack Lin,
- Nicole Y. Phan,
- Gaston Habets,
- Andrey Rymar,
- Garson Tsang,
- Jason Walters,
- Marika Nespi,
- Parmveer Singh,
- Stephanie Broome,
- Prabha Ibrahim,
- Chao Zhang,
- Gideon Bollag,
- Brian L. West,
- Kim N. Green
Affiliations
- Elizabeth Spangenberg
- Department of Neurobiology and Behavior, University of California Irvine (UCI)
- Paul L. Severson
- Plexxikon Inc
- Lindsay A. Hohsfield
- Department of Neurobiology and Behavior, University of California Irvine (UCI)
- Joshua Crapser
- Department of Neurobiology and Behavior, University of California Irvine (UCI)
- Jiazhong Zhang
- Plexxikon Inc
- Elizabeth A. Burton
- Plexxikon Inc
- Ying Zhang
- Plexxikon Inc
- Wayne Spevak
- Plexxikon Inc
- Jack Lin
- Plexxikon Inc
- Nicole Y. Phan
- Department of Neurobiology and Behavior, University of California Irvine (UCI)
- Gaston Habets
- Plexxikon Inc
- Andrey Rymar
- Plexxikon Inc
- Garson Tsang
- Plexxikon Inc
- Jason Walters
- Plexxikon Inc
- Marika Nespi
- Plexxikon Inc
- Parmveer Singh
- Plexxikon Inc
- Stephanie Broome
- Plexxikon Inc
- Prabha Ibrahim
- Plexxikon Inc
- Chao Zhang
- Plexxikon Inc
- Gideon Bollag
- Plexxikon Inc
- Brian L. West
- Plexxikon Inc
- Kim N. Green
- Department of Neurobiology and Behavior, University of California Irvine (UCI)
- DOI
- https://doi.org/10.1038/s41467-019-11674-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 21
Abstract
Genetics implicate microglia in Alzheimer’s disease pathogenesis, but their roles remain unclear. Here, the authors find that microglial depletion in a mouse model of Alzheimer’s disease impairs plaque formation and that Aβ-induced changes in neuronal gene expression are microglia-mediated.
