Evidences of a New Psychobiotic Formulation on Body Composition and Anxiety

Carmela Colica; Ennio Avolio; Patrizio Bollero; Renata Costa de Miranda; Simona Ferraro; Paola Sinibaldi Salimei; Antonino De Lorenzo; Laura Di Renzo

doi:10.1155/2017/5650627

Mediators of Inflammation (Jan 2017)

Evidences of a New Psychobiotic Formulation on Body Composition and Anxiety

Carmela Colica,
Ennio Avolio,
Patrizio Bollero,
Renata Costa de Miranda,
Simona Ferraro,
Paola Sinibaldi Salimei,
Antonino De Lorenzo,
Laura Di Renzo

Affiliations

Carmela Colica: CNR, IBFM UOS of Germaneto, University “Magna Graecia” of Catanzaro, Campus “Salvatore Venuta”, Germaneto, 88100 Catanzaro, Italy
Ennio Avolio: Comparative Neuroanatomy Laboratory of Ecology Department, University of Calabria, Ponte Pietro Bucci, Arcavacata di Rende, 87030 Cosenza, Italy
Patrizio Bollero: Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Renata Costa de Miranda: PhD School of Medical-Surgical Applied Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Simona Ferraro: Health Center Srl, Biomedical and Nutritional Center, 87100 Cosenza, Italy
Paola Sinibaldi Salimei: Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Antonino De Lorenzo: Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Laura Di Renzo: Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

DOI: https://doi.org/10.1155/2017/5650627
Journal volume & issue: Vol. 2017

Abstract

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Background. Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods. Eligible patients were randomly divided into three groups: psychobiotics oral suspension group (POSG); dietary treatment group (DTG); combined treatment group (CTG). All subjects underwent body composition and psychological profile evaluation. Results. Significant changes in body composition parameters in each group were relieved after all treatments. Hamilton anxiety rating scale (HAM-A) highlighted a significant reduction of the total score for all study population after treatments in POSG (p=0.01) and CTG (p=0.04). A reduction of HAM-A total score in anxious subjects in POSG or CTG and a significant reduction of positive subjects for HAM-A in POSG (p=0.03) and in CDG (p=0.01) were shown. Discussion. Three-week intake of selected POS represents a good approach to solve problems related to obesity and behavior disorders. However, new clinical trials need to be performed on a larger population and for a longer period of treatment before definitive conclusions can be made. This trial is registered with NCT01890070.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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