Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis
Yaping Wang,
Yufan Wang,
Haiyan Wang,
Liang Ma,
Simon B. Eickhoff,
Kristoffer Hougaard Madsen,
Congying Chu,
Lingzhong Fan
Affiliations
Yaping Wang
Sino-Danish Center, University of Chinese Academy of Sciences, Beijing 100190, China; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
Yufan Wang
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
Haiyan Wang
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
Liang Ma
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
Simon B. Eickhoff
Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, 52425 Jülich, Germany; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany
Kristoffer Hougaard Madsen
Sino-Danish Center, University of Chinese Academy of Sciences, Beijing 100190, China; Department of Applied Mathematics and Computer Science, Technical University of Denmark, 2800 Kongens Lyngby, Denmark; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, 2650 Hvidovre, Denmark
Congying Chu
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Corresponding author
Lingzhong Fan
Sino-Danish Center, University of Chinese Academy of Sciences, Beijing 100190, China; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266000, China; Corresponding author
Summary: Cerebellar involvement in both motor and non-motor functions manifests in specific regions of the human cerebellum, revealing the functional heterogeneity within it. One compelling theory places the heterogeneity within the cerebellar functional hierarchy along the sensorimotor-association (SA) axis. Despite extensive neuroimaging studies, evidence for the cerebellar SA axis from different modalities and scales was lacking. Thus, we establish a significant link between the cerebellar SA axis and spatio-molecular profiles. Utilizing the gene set variation analysis, we find the intermediate biological principles the significant genes leveraged to scaffold the cerebellar SA axis. Interestingly, we find these spatio-molecular profiles notably associated with neuropsychiatric dysfunction and recent evolution. Furthermore, cerebello-cerebral interactions at genetic and functional connectivity levels mirror the cerebral cortex and cerebellum’s SA axis. These findings can provide a deeper understanding of how the human cerebellar SA axis is shaped and its role in transitioning from sensorimotor to association functions.
