Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos

Lei Li; Rossella Rispoli; Roger Patient; Aldo Ciau-Uitz; Catherine Porcher

doi:10.1038/s41467-019-09050-y

Nature Communications (Mar 2019)

Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos

Lei Li,
Rossella Rispoli,
Roger Patient,
Aldo Ciau-Uitz,
Catherine Porcher

Affiliations

Lei Li: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Rossella Rispoli: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Roger Patient: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Aldo Ciau-Uitz: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Catherine Porcher: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford

DOI: https://doi.org/10.1038/s41467-019-09050-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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How vegfa expression is transcriptionally regulated in vivo is unclear. Here, the authors demonstrate that the ETS transcription factor Etv6 acts as a repressor and an activator of two direct regulators of vegfa expression (foxo3 and klf4, respectively) to control blood formation in Xenopus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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