Nature Communications (Feb 2017)
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
- Anren Song,
- Yujin Zhang,
- Leng Han,
- Gennady G. Yegutkin,
- Hong Liu,
- Kaiqi Sun,
- Angelo D’Alessandro,
- Jessica Li,
- Harry Karmouty-Quintana,
- Takayuki Iriyama,
- Tingting Weng,
- Shushan Zhao,
- Wei Wang,
- Hongyu Wu,
- Travis Nemkov,
- Andrew W. Subudhi,
- Sonja Jameson-Van Houten,
- Colleen G. Julian,
- Andrew T. Lovering,
- Kirk C. Hansen,
- Hong Zhang,
- Mikhail Bogdanov,
- William Dowhan,
- Jianping Jin,
- Rodney E. Kellems,
- Holger K. Eltzschig,
- Michael Blackburn,
- Robert C. Roach,
- Yang Xia
Affiliations
- Anren Song
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Yujin Zhang
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Leng Han
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Gennady G. Yegutkin
- Medicity Research Laboratory, University of Turku
- Hong Liu
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Kaiqi Sun
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Angelo D’Alessandro
- Department of Biochemistry and Molecular Genetics, University of Colorado
- Jessica Li
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Harry Karmouty-Quintana
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Takayuki Iriyama
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Tingting Weng
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Shushan Zhao
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Wei Wang
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Hongyu Wu
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Travis Nemkov
- Department of Emergency Medicine University of Colorado School of Medicine, Altitude Research Center
- Andrew W. Subudhi
- Department of Emergency Medicine University of Colorado School of Medicine, Altitude Research Center
- Sonja Jameson-Van Houten
- Department of Emergency Medicine University of Colorado School of Medicine, Altitude Research Center
- Colleen G. Julian
- Department of Emergency Medicine University of Colorado School of Medicine, Altitude Research Center
- Andrew T. Lovering
- Department of Emergency Medicine University of Colorado School of Medicine, Altitude Research Center
- Kirk C. Hansen
- Department of Biochemistry and Molecular Genetics, University of Colorado
- Hong Zhang
- Department of Pathology, MD Anderson Cancer Center
- Mikhail Bogdanov
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- William Dowhan
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Jianping Jin
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Rodney E. Kellems
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Holger K. Eltzschig
- Department of Anesthesiology, Organ Protection Program, University of Colorado School of Medicine
- Michael Blackburn
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Robert C. Roach
- Department of Emergency Medicine University of Colorado School of Medicine, Altitude Research Center
- Yang Xia
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- DOI
- https://doi.org/10.1038/ncomms14108
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Humans that reach high altitude soon after the first ascent show faster adaptation to hypoxia. Songet al. show that this adaptive response relies on decreased red blood cell uptake of plasma adenosine due to reduced levels of nucleoside transporter ENT1 resulting from coordinated adenosine generation by ectonucleotidase CD73 and activation of A2B receptors.
