Iron limitation in M. tuberculosis has broad impact on central carbon metabolism

Monique E. Theriault; Davide Pisu; Kaley M. Wilburn; Gabrielle Lê-Bury; Case W. MacNamara; H. Michael Petrassi; Melissa Love; Jeremy M. Rock; Brian C. VanderVen; David G. Russell

doi:10.1038/s42003-022-03650-z

Communications Biology (Jul 2022)

Iron limitation in M. tuberculosis has broad impact on central carbon metabolism

Monique E. Theriault,
Davide Pisu,
Kaley M. Wilburn,
Gabrielle Lê-Bury,
Case W. MacNamara,
H. Michael Petrassi,
Melissa Love,
Jeremy M. Rock,
Brian C. VanderVen,
David G. Russell

Affiliations

Monique E. Theriault: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University
Davide Pisu: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University
Kaley M. Wilburn: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University
Gabrielle Lê-Bury: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University
Case W. MacNamara: California Institute for Biomedical Research (Calibr)
H. Michael Petrassi: California Institute for Biomedical Research (Calibr)
Melissa Love: California Institute for Biomedical Research (Calibr)
Jeremy M. Rock: Department of Host-Pathogen Biology, The Rockefeller University
Brian C. VanderVen: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University
David G. Russell: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University

DOI: https://doi.org/10.1038/s42003-022-03650-z
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

Read online

An inhibitor of Mycobacterium tuberculosis (Mtb) survival acts as an iron chelator, demonstrating that iron deprivation alters Mtb cholesterol and central carbon metabolism.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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