The intervention effect of different distribution ratio of Astragalus total saponins and curcumin on the DM rats model

Abstract

Through the study of the effect of different ratio of Astragalus Total Saponins (ATS) and curcumin on Diabetes Mellitu (DM) model rats, we want to improve the screening model of the distribution ratio in Chinese Medicine, screening out the optimal proportion of the prevention and control of DM. By injecting streptozotocin (STZ) in the tail vein of rats to induct the DM rats model, we measured the dynamic change, insulin and insulin antibody (IAA) levels, glycosylated serum protein (GSP) content, lipid metabolism and the changes of renal pathology in DM model rats. The different distribution ratio of ATS and Curcumin can significantly reduce GSP, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL); significantly increased serum insulin levels and high density lipoprotein (HDL) content, significantly decreased IAA level on the DM rats model induced by STZ. Different proportions of ATS and Curcumin have a good therapeutic effect on DM model rats, and 6:4 is the optimal proportion for the prevention and treatment of DM. Keywords: Astragalus total saponins (ATS), Curcumin, Different proportion, Rats, Diabetes model