Zhongguo quanke yixue (Aug 2024)

Advances in Exploring the Interaction between Paneth Cells and Intestinal Stem Cells and Possible Targets for Traditional Chinese Medicine Based on Mitochondrial Function and Energy Metabolism

  • LUO Guoliang, ZHANG Xindan, TANG Taichun, ZHU Yan, WANG Shuting, CHEN Min

DOI
https://doi.org/10.12114/j.issn.1007-9572.2023.0574
Journal volume & issue
Vol. 27, no. 23
pp. 2864 – 2868

Abstract

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Intestinal stem cells and Paneth cells interact with each other to maintain intestinal homeostasis and function, the interaction between intestinal stem cells and Paneth cells is regulated by mitochondria-related functions and energy conversion. The unique advantages of traditional Chinese medicine (TCM) in the treatment of intestinal diseases are also reflected in its effects on mitochondria and energy metabolism. This paper explores the influence of mitochondrial function and energy metabolism on the interaction between intestinal stem cells and Paneth cells, as well as the possible targets related to mitochondria in the treatment of intestinal diseases by TCM, summarizes the regulatory effects of TCM on mitochondria and energy metabolism, thereby restoring intestinal homeostasis and alleviating disease, with an aim to provide reference and theoretical basis for the research related to the TCM treatment of intestinal stem cells and Paneth cells based on mitochondria.

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