Nature Communications (Jan 2019)
Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland
- Mitja I. Kurki,
- Elmo Saarentaus,
- Olli Pietiläinen,
- Padhraig Gormley,
- Dennis Lal,
- Sini Kerminen,
- Minna Torniainen-Holm,
- Eija Hämäläinen,
- Elisa Rahikkala,
- Riikka Keski-Filppula,
- Merja Rauhala,
- Satu Korpi-Heikkilä,
- Jonna Komulainen–Ebrahim,
- Heli Helander,
- Päivi Vieira,
- Minna Männikkö,
- Markku Peltonen,
- Aki S. Havulinna,
- Veikko Salomaa,
- Matti Pirinen,
- Jaana Suvisaari,
- Jukka S. Moilanen,
- Jarmo Körkkö,
- Outi Kuismin,
- Mark J. Daly,
- Aarno Palotie
Affiliations
- Mitja I. Kurki
- Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston
- Elmo Saarentaus
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Olli Pietiläinen
- The Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard
- Padhraig Gormley
- Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston
- Dennis Lal
- Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston
- Sini Kerminen
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Minna Torniainen-Holm
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Eija Hämäläinen
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Elisa Rahikkala
- PEDEGO Research Unit, University of Oulu
- Riikka Keski-Filppula
- PEDEGO Research Unit, University of Oulu
- Merja Rauhala
- Northern Ostrobothnia Hospital District, Center for Intellectual Disability Care
- Satu Korpi-Heikkilä
- Northern Ostrobothnia Hospital District, Center for Intellectual Disability Care
- Jonna Komulainen–Ebrahim
- Department of Children and Adolescents, Oulu University Hospital, Medical Research Center Oulu, University of Oulu
- Heli Helander
- Department of Children and Adolescents, Oulu University Hospital, Medical Research Center Oulu, University of Oulu
- Päivi Vieira
- Department of Children and Adolescents, Oulu University Hospital, Medical Research Center Oulu, University of Oulu
- Minna Männikkö
- Center for Life Course Health Research, Faculty of Medicine, University of Oulu
- Markku Peltonen
- National Institute for Health and Welfare
- Aki S. Havulinna
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Veikko Salomaa
- National Institute for Health and Welfare
- Matti Pirinen
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Jaana Suvisaari
- National Institute for Health and Welfare
- Jukka S. Moilanen
- PEDEGO Research Unit, University of Oulu
- Jarmo Körkkö
- Northern Ostrobothnia Hospital District, Center for Intellectual Disability Care
- Outi Kuismin
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Mark J. Daly
- Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston
- Aarno Palotie
- Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston
- DOI
- https://doi.org/10.1038/s41467-018-08262-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Various types of genetic variation contribute to the etiology of intellectual disability (ID). Here, the authors study a cohort of ID patients enriched for mild ID from Finland, to investigate contributions of rare and common variants associated with ID of different levels of severity.
