Photodynamic and ferroptotic Ce6@ZIF-8@ssPDA for head and neck cancer treatment

Miaochen Wang; Fan Li; Tingwei Lu; Ruoyi Wu; Shengbing Yang; Wantao Chen

Materials & Design (Dec 2022)

Photodynamic and ferroptotic Ce6@ZIF-8@ssPDA for head and neck cancer treatment

Miaochen Wang,
Fan Li,
Tingwei Lu,
Ruoyi Wu,
Shengbing Yang,
Wantao Chen

Affiliations

Miaochen Wang: Department of Oral and Maxillofacial-Head & Neck Oncology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China
Fan Li: Department of Oral and Maxillofacial-Head & Neck Oncology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China
Tingwei Lu: Department of Oral and Maxillofacial-Head & Neck Oncology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China
Ruoyi Wu: Department of Oral and Maxillofacial-Head & Neck Oncology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China
Shengbing Yang: Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, China; Corresponding authors at: Department of Oral and Maxillofacial-Head & Neck Oncology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Wantao Chen: Department of Oral and Maxillofacial-Head & Neck Oncology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Corresponding authors at: Department of Oral and Maxillofacial-Head & Neck Oncology, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Journal volume & issue: Vol. 224
p. 111403

Abstract

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Nanomedicine delivery systems combined with photodynamic therapy, improve targeted cancer enrichment, reduce side effects, and enhance anticancer efficacy. Additionally, ferroptosis has emerged as a novel cancer-killing mechanism, with great potential in cancer treatment. The study aimed to treat head and neck cancers by manufacturing ZIF-8@ssPDA as a drug carrier for the chlorin e6 (Ce6) photosensitizer in response to dual stimuli of the tumor microenvironment. The ZIF-8 structure can efficiently load Ce6, and polydopamine modified with a disulfide bond (ssPDA) is evenly and densely distributed on the ZIF-8 surface. In tumor microenvironments where glutathione (GSH) concentrations are high, the ssPDA structure ruptures, directly consuming GSH and further inactivating GPX4, thereby establishing a specific anticancer effect through the ferroptosis pathway. Furthermore, the Ce6@ZIF-8 structure responsively collapses in the acidic tumor microenvironment, releasing loaded Ce6. Under the excitation of a 660-nm near-infrared laser, large singlet oxygen can be generated from released Ce6 within a short period, exerting a strong photodynamic anticancer effect. Depending on the characteristic tumor microenvironment with high GSH level and acidic environment, this dual-responsive strategy combines a photodynamic and ferroptotic effect; it might improve the treatment efficacy of head and neck cancers.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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