The progress of research into the role of D-lactic acid in the diagnosis of periprosthetic joint infection

Abstract

Periprosthetic joint infection is a catastrophic complication after arthroplasty. However, at present, there is still no accurate and efficient method for the diagnosis of this serious problem. The most widely accepted diagnostic criteria of periprosthetic infection have been developed by the Ameri-can Musculoskeletal Infection Society but their complex clinical indicators are not readily available for clinical application. Some laboratory tests such as white blood cell count, erythrocyte sedimentation rate, C-reactive protein, interleukin and serum procalcitonin have a certain diagnostic value. However, these tests are easily affected by other factors such as systemic diseases, infections at other sites and the use of antibiotics. In recent years, increasingly attention has been paid to the value of synovial fluid bi-omarkers in the diagnosis of periprosthetic joint infection. In this article, we have reviewed the current clinical studies related to synovial fluid D-lactate and have analyzed the clinical value and research sta-tus of D-lactate in the diagnosis of periprosthetic joint infection.

Keywords

• periprosthetic joint infection
• biomarker
• synovial fluid
• d-lactate