Nature Communications (Mar 2021)

Nonlinear delay differential equations and their application to modeling biological network motifs

  • David S. Glass,
  • Xiaofan Jin,
  • Ingmar H. Riedel-Kruse

DOI
https://doi.org/10.1038/s41467-021-21700-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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Network motif models focus on small sub-networks in biological systems to quantitatively describe overall behavior but they often overlook time delays. Here, the authors systematically examine the most common network motifs via delay differential equations (DDE), often leading to more concise descriptions.