Dihydroquinazolinones as adaptative C(sp 3) handles in arylations and alkylations via dual catalytic C–C bond-functionalization

Abstract

Although derived from feedstock chemicals and therefore in principle abundant, ketones are not widely used as cross-coupling partners in organic synthesis. Herein, the authors use ketone derivatives as one-electron handles for forging C(sp3) architectures via dual photo- and nickel catalysis.