Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere
Dorit Kliemann,
Ralph Adolphs,
J. Michael Tyszka,
Bruce Fischl,
B.T. Thomas Yeo,
Remya Nair,
Julien Dubois,
Lynn K. Paul
Affiliations
Dorit Kliemann
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA; Corresponding author
Ralph Adolphs
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
J. Michael Tyszka
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
Bruce Fischl
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, Boston, MA 02114, USA; Division of Health Sciences and Technology and Engineering and Computer Science MIT, Cambridge, MA 02139, USA
B.T. Thomas Yeo
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Electrical and Computer Engineering, Centre for Sleep and Cognition, Clinical Imaging Research Centre, N.1 Institute for Health and Memory Networks Program, National University of Singapore, Singapore 119077, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 119077, Singapore
Remya Nair
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
Julien Dubois
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
Lynn K. Paul
Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
Summary: A reliable set of functional brain networks is found in healthy people and thought to underlie our cognition, emotion, and behavior. Here, we investigated these networks by quantifying intrinsic functional connectivity in six individuals who had undergone surgical removal of one hemisphere. Hemispherectomy subjects and healthy controls were scanned with identical parameters on the same scanner and compared to a large normative sample (n = 1,482). Surprisingly, hemispherectomy subjects and controls all showed strong and equivalent intrahemispheric connectivity between brain regions typically assigned to the same functional network. Connectivity between parts of different networks, however, was markedly increased for almost all hemispherectomy participants and across all networks. These results support the hypothesis of a shared set of functional networks that underlie cognition and suggest that between-network interactions may characterize functional reorganization in hemispherectomy. : Kliemann et al. present resting state neuroimaging data in six adults with childhood hemispherectomy, compared to controls. They find an intact functional organization into canonical networks, yet identify an increase in communication between networks—a possible characterization of functional reorganization in hemispherectomy. Keywords: hemispherectomy, functional connectivity, plasticity, brain networks, fMRI
