Nature Communications (Sep 2019)

Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy

  • Brenda Janice Sánchez,
  • Anne-Marie K. Tremblay,
  • Jean-Philippe Leduc-Gaudet,
  • Derek T. Hall,
  • Erzsebet Kovacs,
  • Jennifer F. Ma,
  • Souad Mubaid,
  • Patricia L. Hallauer,
  • Brittany L. Phillips,
  • Katherine E. Vest,
  • Anita H. Corbett,
  • Dimitris L. Kontoyiannis,
  • Sabah N. A. Hussain,
  • Kenneth E. M. Hastings,
  • Sergio Di Marco,
  • Imed-Eddine Gallouzi

DOI
https://doi.org/10.1038/s41467-019-12186-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

Read online

HuR is an RNA-binding protein that regulates myotube differentiation in vitro. Here, the authors show that the muscle-specific ablation of HuR in mice leads to enhanced endurance capacity and an increase in oxidative fibres by destabilising PGC1α-mRNA, and show that the mice are protected against cancer cachexia