Nature Communications (Sep 2019)
Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy
- Brenda Janice Sánchez,
- Anne-Marie K. Tremblay,
- Jean-Philippe Leduc-Gaudet,
- Derek T. Hall,
- Erzsebet Kovacs,
- Jennifer F. Ma,
- Souad Mubaid,
- Patricia L. Hallauer,
- Brittany L. Phillips,
- Katherine E. Vest,
- Anita H. Corbett,
- Dimitris L. Kontoyiannis,
- Sabah N. A. Hussain,
- Kenneth E. M. Hastings,
- Sergio Di Marco,
- Imed-Eddine Gallouzi
Affiliations
- Brenda Janice Sánchez
- Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler
- Anne-Marie K. Tremblay
- Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler
- Jean-Philippe Leduc-Gaudet
- Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, and Department of Critical Care, McGill University Health Centre Research Institute
- Derek T. Hall
- Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler
- Erzsebet Kovacs
- Rosalind & Morris Goodman Cancer Research Center, McGill University, 3655 Promenade Sir William Osler
- Jennifer F. Ma
- Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler
- Souad Mubaid
- Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler
- Patricia L. Hallauer
- Montreal Neurological Institute, McGill University
- Brittany L. Phillips
- Department of Biology, Emory University
- Katherine E. Vest
- Department of Molecular Genetics, Biochemistry, & Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way
- Anita H. Corbett
- Department of Biology, Emory University
- Dimitris L. Kontoyiannis
- Biomedical Sciences Research Centre “Alexander Fleming”, Institute of Fundamental Biomedical Research
- Sabah N. A. Hussain
- Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, and Department of Critical Care, McGill University Health Centre Research Institute
- Kenneth E. M. Hastings
- Montreal Neurological Institute, McGill University
- Sergio Di Marco
- Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler
- Imed-Eddine Gallouzi
- Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler
- DOI
- https://doi.org/10.1038/s41467-019-12186-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
HuR is an RNA-binding protein that regulates myotube differentiation in vitro. Here, the authors show that the muscle-specific ablation of HuR in mice leads to enhanced endurance capacity and an increase in oxidative fibres by destabilising PGC1α-mRNA, and show that the mice are protected against cancer cachexia
