Nature Communications (Apr 2021)

Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

  • Hao Huang,
  • Jianyang Hu,
  • Alishba Maryam,
  • Qinghua Huang,
  • Yuchen Zhang,
  • Saravanan Ramakrishnan,
  • Jingyu Li,
  • Haiying Ma,
  • Victor W. S. Ma,
  • Wah Cheuk,
  • Grace Y. K. So,
  • Wei Wang,
  • William C. S. Cho,
  • Liang Zhang,
  • Kui Ming Chan,
  • Xin Wang,
  • Y. Rebecca Chin

DOI
https://doi.org/10.1038/s41467-021-22445-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognostic outcomes. Here the authors characterize super-enhancer heterogeneity and they identify genes that are specifically regulated by TNBC-specific super-enhancers, including FOXC1, MET and ANLN.