Nature Communications (Mar 2020)

Predicting gene expression using morphological cell responses to nanotopography

  • Marie F. A. Cutiongco,
  • Bjørn Sand Jensen,
  • Paul M. Reynolds,
  • Nikolaj Gadegaard

DOI
https://doi.org/10.1038/s41467-020-15114-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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The surface nanotopography of biomaterials direct cell behavior, but screening for desired effects is inefficient. Here, the authors introduce a platform that enables prediction of nanotopography-induced gene expression changes from changes in cell morphology, including in co-culture environments.