European Journal of Case Reports in Internal Medicine (Sep 2024)

DIPNECH: a rare cause of slow-growing pulmonary nodules in a dyspnoeic patient with a history of breast cancer

  • Peter Cassar,
  • Dione Buhagiar,
  • Jonathan Gauci,
  • Kyra Bartolo,
  • Adrian Mizzi,
  • Andrew Mallia,
  • Josef Micallef

DOI
https://doi.org/10.12890/2024_004870

Abstract

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A middle-aged woman undergoing a computed tomography scan while being investigated for a retrosternal goitre, was found to have several solid intrapulmonary nodules of varying sizes with mosaic attenuation of lung parenchyma. After serial radiology follow-up, a radiologist with a special interest in thoracic imaging made the tentative diagnosis of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) during discussions at the local multidisciplinary team meeting. Radionuclide imaging was performed to assist in reaching a diagnosis. Uptake of DOTATATE by the pulmonary nodules on a background of mosaic attenuation pattern supported a diagnosis of DIPNECH. Potential secondary metastatic disease from previous breast malignancy confounded a possible earlier diagnosis of DIPNECH, with subsequent diagnostic imaging modalities leading to the rare diagnosis. The patient was treated symptomatically with oral steroids with no improvement, and subsequently with octreotide which significantly improved her condition.

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