Nature Communications (Sep 2017)

Timely regulated sorting from early to late endosomes is required to maintain cerebellar long-term depression

  • Taegon Kim,
  • Yukio Yamamoto,
  • Keiko Tanaka-Yamamoto

DOI
https://doi.org/10.1038/s41467-017-00518-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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Long term depression (LTD) of the cerebellum is known to be mediated by postsynaptic trafficking of glutamate receptor AMPAR. Here, Kim and colleagues show that early- to late-endosomal sorting of AMPAR represents the switch from expression to maintenance phase of cerebellar LTD.