Biological functions and molecular mechanisms of LINC01116 in cancer
Ke Shi,
Xue-Ying Wang,
Li-De Huang,
Qiang Guo,
Wei Yuan,
Yan Lv,
Dan Li
Affiliations
Ke Shi
Department of Thoracic Surgery, Beilun District People's Hospital of Ningbo, Ningbo City, China
Xue-Ying Wang
Department of Cardiothoracic Surgery, Taihe Hospital, Hubei Medical University, Shiyan City, China; Department of Basic Medicine, Hubei University of Medicine, Shiyan City, China
Li-De Huang
Department of Pain management, People's Hospital of Shiyan City, Hubei Medical University, Shiyan City, China
Qiang Guo
Department of Cardiothoracic Surgery, Taihe Hospital, Hubei Medical University, Shiyan City, China
Wei Yuan
Department of Basic Medicine, Hubei University of Medicine, Shiyan City, China; Corresponding author.
Yan Lv
Department of Thoracic Surgery, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, China; Corresponding author.
Dan Li
Department of Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan City, China; Corresponding author.
LINC01116, a long non-coding RNA (lncRNA), serves as an important regulator in the progression of cancer cells and has attracted increased attention in biological fields. It is overexpressed in various cancer cells and is significantly correlated with cancer development and poor prognosis in cancer patients. Moreover, LINC01116 regulates the gene expression of various cancers through intricate pathways, such as sponging the microRNAs or other non-genic manners. These signaling pathways greatly affect the cancer's biological functions, including cell growth, migration, invasion, and chemoresistance. Hence, LINC01116 may serve as a prognostic biomarker and therapeutic target for human cancer. This paper summarizes the current evidence regarding the biological functions and molecular mechanisms of LINC01116 in the progression of cancer, providing theoretical references for LINC01116-related cancer treatment in the future.
