NY-ESO-1-specific redirected T cells with endogenous TCR knockdown mediate tumor response and cytokine release syndrome

• Takashi Kojima,
• Hiroaki Ikeda,
• Sachiko Okamoto,
• Junichi Mineno,
• Hiroshi Shiku,
• Shigehisa Kitano,
• Shinichi Kageyama,
• Yoshihiro Miyahara,
• Mikiya Ishihara,
• Daisuke Tomura,
• Ikuei Nukaya,
• Tetsuro Sasada,
• Noboru Yamamoto,
• Takashi Watanabe,
• Hideyuki Mishima,
• Alessandra Nardin,
• Evan Newell,
• Hidefumi Kato,
• Hiroyoshi Hattori,
• Takeru Funakoshi,
• Eiichi Sato,
• Hideto Chono,
• Muhammad Faris Kairi,
• Phuong Diem Hoang Nguyen,
• Yannick Simoni,
• Michael Fehlings

Affiliations

Takashi Kojima

Ophthalmology, Nagoya Eye Clinic, Nagoya, Japan

Hiroaki Ikeda

Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Sachiko Okamoto

1Takara Bio Inc., Kusatsu, Shiga, Japan

Junichi Mineno

1Takara Bio Inc., Kusatsu, Shiga, Japan

Hiroshi Shiku

Aff1 grid.260026.0000000040372555XDepartment of Immuno-Gene TherapyMie University Graduate School of medicine Tsu Japan

Shigehisa Kitano

Department of Experimental Therapeutics, National Cancer Center Hospital, Goyang, Republic of Korea

Shinichi Kageyama

Aff1 grid.260026.0000000040372555XDepartment of Immuno-Gene TherapyMie University Graduate School of Medicine Mie, Tsu Japan

Yoshihiro Miyahara

Aff1 grid.260026.0000000040372555XDepartment of Immuno-Gene TherapyMie University Graduate School of Medicine Mie, Tsu Japan

Mikiya Ishihara

Aff1 grid.260026.0000000040372555XDepartment of Immuno-Gene TherapyMie University Graduate School of Medicine Mie, Tsu Japan

Daisuke Tomura

Aff3 grid.410820.fCenter for Cell and Gene TherapyTakara Bio Inc. Shiga Japan

Ikuei Nukaya

Aff3 grid.410820.fCenter for Cell and Gene TherapyTakara Bio Inc. Shiga Japan

Tetsuro Sasada

Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan

Noboru Yamamoto

Department of Experimental Therapeutics, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan

Takashi Watanabe

Department of General Thoracic Surgery, Nara Prefecture General Medical Center, Nara, Japan

Hideyuki Mishima

2Cancer Center, Aichi Medical University, Yazakokarimata, Japan

Alessandra Nardin

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore

Evan Newell

1Fred Hutchinson Cancer Research Center, Seattle, WA, USA

Hidefumi Kato

Department of Transfusion Medicine, Aichi Medical University, Nagakute, Japan

Hiroyoshi Hattori

Laboratory of Advanced Therapy, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan

Takeru Funakoshi

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan

Eiichi Sato

Institute of Medical Science, Tokyo Medical University, Tokyo, Japan

Hideto Chono

Takara Bio Inc, Kusatsu, Japan

Muhammad Faris Kairi

ImmunoScape Pte. Ltd, Singapore

Phuong Diem Hoang Nguyen

ImmunoScape Pte. Ltd, Singapore

Yannick Simoni

ImmunoScape Pte. Ltd, Singapore

Michael Fehlings

ImmunoScape Pte. Ltd, Singapore