Nature Communications (Oct 2022)
Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes
- Shin-ichi Ikeda,
- Toshihide Kurihara,
- Xiaoyan Jiang,
- Yukihiro Miwa,
- Deokho Lee,
- Naho Serizawa,
- Heonuk Jeong,
- Kiwako Mori,
- Yusaku Katada,
- Hiromitsu Kunimi,
- Nobuhiro Ozawa,
- Chiho Shoda,
- Mari Ibuki,
- Kazuno Negishi,
- Hidemasa Torii,
- Kazuo Tsubota
Affiliations
- Shin-ichi Ikeda
- Laboratory of Photobiology, Keio University School of Medicine
- Toshihide Kurihara
- Laboratory of Photobiology, Keio University School of Medicine
- Xiaoyan Jiang
- Laboratory of Photobiology, Keio University School of Medicine
- Yukihiro Miwa
- Laboratory of Photobiology, Keio University School of Medicine
- Deokho Lee
- Laboratory of Photobiology, Keio University School of Medicine
- Naho Serizawa
- Laboratory of Photobiology, Keio University School of Medicine
- Heonuk Jeong
- Laboratory of Photobiology, Keio University School of Medicine
- Kiwako Mori
- Laboratory of Photobiology, Keio University School of Medicine
- Yusaku Katada
- Laboratory of Photobiology, Keio University School of Medicine
- Hiromitsu Kunimi
- Laboratory of Photobiology, Keio University School of Medicine
- Nobuhiro Ozawa
- Laboratory of Photobiology, Keio University School of Medicine
- Chiho Shoda
- Laboratory of Photobiology, Keio University School of Medicine
- Mari Ibuki
- Laboratory of Photobiology, Keio University School of Medicine
- Kazuno Negishi
- Department of Ophthalmology, Keio University School of Medicine
- Hidemasa Torii
- Laboratory of Photobiology, Keio University School of Medicine
- Kazuo Tsubota
- Department of Ophthalmology, Keio University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33605-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
he underlying mechanism of myopic axial elongation of the eyes has long been unknown. Here, the authors show that endoplasmic reticulum stress in the sclera and its sensor proteins, PERK and ATF6, are involved in myopic axial elongation
