Nature Communications (Sep 2017)
Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood
- Samuel W. Lukowski,
- Luke R. Lloyd-Jones,
- Alexander Holloway,
- Holger Kirsten,
- Gibran Hemani,
- Jian Yang,
- Kerrin Small,
- Jing Zhao,
- Andres Metspalu,
- Emmanouil T. Dermitzakis,
- Greg Gibson,
- Timothy D. Spector,
- Joachim Thiery,
- Markus Scholz,
- Grant W. Montgomery,
- Tonu Esko,
- Peter M. Visscher,
- Joseph E. Powell
Affiliations
- Samuel W. Lukowski
- Institute for Molecular Bioscience, University of Queensland
- Luke R. Lloyd-Jones
- Institute for Molecular Bioscience, University of Queensland
- Alexander Holloway
- Centre for Neurogenetics and Statistical Genomics, Queensland Brain Institute, University of Queensland
- Holger Kirsten
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Gibran Hemani
- MRC Integrative Epidemiology Unit (IEU) at the University of Bristol
- Jian Yang
- Institute for Molecular Bioscience, University of Queensland
- Kerrin Small
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Jing Zhao
- School of Biology and Center for Integrative Genomics, Georgia Institute of Technology
- Andres Metspalu
- Estonian Genome Center, University of Tartu
- Emmanouil T. Dermitzakis
- Department of Genetic Medicine and Development, University of Geneva
- Greg Gibson
- School of Biology and Center for Integrative Genomics, Georgia Institute of Technology
- Timothy D. Spector
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Joachim Thiery
- LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig
- Markus Scholz
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Grant W. Montgomery
- Institute for Molecular Bioscience, University of Queensland
- Tonu Esko
- Estonian Genome Center, University of Tartu
- Peter M. Visscher
- Institute for Molecular Bioscience, University of Queensland
- Joseph E. Powell
- Institute for Molecular Bioscience, University of Queensland
- DOI
- https://doi.org/10.1038/s41467-017-00473-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Covariance of gene expression pairs is due to a combination of shared genetic and environmental factors. Here the authors estimate the genetic correlation between highly heritable pairs and identify transcription factor control and chromatin interactions as possible mechanisms of correlation.
