SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

Sifan Chen; Maximilian Felix Blank; Aishwarya Iyer; Bingding Huang; Lin Wang; Ingrid Grummt; Renate Voit

doi:10.1038/ncomms10734

Nature Communications (Feb 2016)

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

Sifan Chen,
Maximilian Felix Blank,
Aishwarya Iyer,
Bingding Huang,
Lin Wang,
Ingrid Grummt,
Renate Voit

Affiliations

Sifan Chen: Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Fed 581, 69120 Heidelberg, Germany
Maximilian Felix Blank: Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Fed 581, 69120 Heidelberg, Germany
Aishwarya Iyer: Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Fed 581, 69120 Heidelberg, Germany
Bingding Huang: Division of Theoretical Bioinformatics, German Cancer Research Center
Lin Wang: Genomics and Proteomics Core Facility, German Cancer Research Center
Ingrid Grummt: Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Fed 581, 69120 Heidelberg, Germany
Renate Voit: Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Fed 581, 69120 Heidelberg, Germany

DOI: https://doi.org/10.1038/ncomms10734
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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SIRT7 is a protein deacetylase with important roles in rRNA synthesis, ribosome biogenesis and cell proliferation. Here the authors show a role of SIRT7 in rRNA maturation via deacetylation of U3-55k, a core component of the U3 snoRNP complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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