Nature Communications (Oct 2017)

A cdk1 gradient guides surface contraction waves in oocytes

  • Johanna Bischof,
  • Christoph A. Brand,
  • Kálmán Somogyi,
  • Imre Májer,
  • Sarah Thome,
  • Masashi Mori,
  • Ulrich S. Schwarz,
  • Péter Lénárt

DOI
https://doi.org/10.1038/s41467-017-00979-6
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

Read online

Surface contraction waves (SCWs) are prominent shape changes coupled to cell cycle transitions in oocytes. Here the authors show that SCWs are patterned by the spatiotemporal integration of two conserved modules, cdk1-cyclinB for cell cycle regulation and RhoA/Rok/NMYII for actomyosin contractility.