Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target

Yuxi Fan; Ye Xu; Zhi Huo; Hedong Zhang; Longkai Peng; Xin Jiang; Angus W. Thomson; Helong Dai; Sihan Zhou; Xiuyuan Hao

doi:10.1097/CM9.0000000000003197

Chinese Medical Journal (Jul 2024)

Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target

Yuxi Fan,
Ye Xu,
Zhi Huo,
Hedong Zhang,
Longkai Peng,
Xin Jiang,
Angus W. Thomson,
Helong Dai,
Sihan Zhou,
Xiuyuan Hao

Affiliations

Yuxi Fan: 1 Department of Immunology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China
Ye Xu: 2 Department of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China
Zhi Huo: 1 Department of Immunology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China
Hedong Zhang: 2 Department of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China
Longkai Peng: 2 Department of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China
Xin Jiang: 4 Department of Organ Transplantation, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People’s Hospital), Zhengzhou, Henan 450000, China
Angus W. Thomson: 5 Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Helong Dai: 2 Department of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China
Sihan Zhou
Xiuyuan Hao

DOI: https://doi.org/10.1097/CM9.0000000000003197
Journal volume & issue: Vol. 137, no. 14
pp. 1663 – 1673

Abstract

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Abstract. Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. As an amplifier of the inflammatory response, TREM-1 is mainly involved in the production of inflammatory mediators and the regulation of cell survival. TREM-1 has been studied in infectious diseases and more recently in non-infectious disorders. More and more studies have shown that TREM-1 plays an important pathogenic role in kidney diseases. There is evidence that TREM-1 can not only be used as a biomarker for diagnosis of disease but also as a potential therapeutic target to guide the development of novel therapeutic agents for kidney disease. This review summarized molecular biology of TREM-1 and its signaling pathways as well as immune response in the progress of acute kidney injury, renal fibrosis, diabetic nephropathy, immune nephropathy, and renal cell carcinoma.

Published in Chinese Medical Journal

ISSN: 0366-6999 (Print); 2542-5641 (Online)
Publisher: Wolters Kluwer
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://journals.lww.com/cmj/pages/default.aspx

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