Composite polymer/wax coatings as a corrosion barrier of bioresorbable magnesium coronary stents
Tonya D. Andreeva,
Oliver Walker,
Alexander Rudt,
Ole Jung,
Mike Barbeck,
Manfred Gülcher,
Rumen Krastev
Affiliations
Tonya D. Andreeva
Faculty “Life Sciences”, Reutlingen University, Alteburgstraße 150, 72762, Reutlingen, Germany; Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. 21, 1113, Sofia, Bulgaria; Corresponding author. Faculty “Life Sciences”, Reutlingen University, Alteburgstraße 150, 72762, Reutlingen, Germany.
Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Strempelstraße 13, 18057, Rostock, Germany
Mike Barbeck
Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Strempelstraße 13, 18057, Rostock, Germany
Manfred Gülcher
QualiMed Innovative Medizinprodukte GmbH, 21423, Winsen, Germany; Subsidiary of Q3 Medical Devices, Ireland
Rumen Krastev
Faculty “Life Sciences”, Reutlingen University, Alteburgstraße 150, 72762, Reutlingen, Germany; Department “Material Development and Functionalization”, NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany; Corresponding author. Faculty “Life Sciences”, Reutlingen University, Alteburgstraße 150, 72762, Reutlingen, Germany.
Magnesium and its alloys are suitable materials for biodegradable biomedical implants such as cardiovascular stents. Here we introduce an innovative composite polyelectrolyte multilayer/wax coating applied to commercial coronary Mg-based stents serving as a barrier layer effectively retarding corrosion. This hydrophobic coating, build by layer-by-layer technology, appeared very thin, smooth, homogeneous, strongly adherent and completely covering the surface of the Mg-stent. In-vitro degradation tests showed greater resistance to degradation of coated Mg-stents compared to uncoated and passivated ones. Cytocompatibility studies proved that Mg-stent coated with the composite coating was non-cytotoxic and improved fibroblast cell viability compared to the uncoated Mg-stent.
