BMC Pulmonary Medicine (Jul 2022)

Associations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study

  • Wenqiao Wang,
  • Jiangtao Lin,
  • Xin Zhou,
  • Changzheng Wang,
  • Mao Huang,
  • Shaoxi Cai,
  • Ping Chen,
  • Qichang Lin,
  • Jianying Zhou,
  • Yuhai Gu,
  • Yadong Yuan,
  • Dejun Sun,
  • Xiaohong Yang,
  • Lan Yang,
  • Jianmin Huo,
  • Zhuochang Chen,
  • Ping Jiang,
  • Jie Zhang,
  • Xianwei Ye,
  • Huiguo Liu,
  • Huaping Tang,
  • Rongyu Liu,
  • Chuntao Liu,
  • Wei Zhang,
  • Chengping Hu,
  • Yiqiang Chen,
  • Xiaoju Liu,
  • Luming Dai,
  • Wei Zhou,
  • Yijiang Huang,
  • Jianying Xu

DOI
https://doi.org/10.1186/s12890-022-02038-3
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 9

Abstract

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Abstract Purpose While asthma comorbidities are associated with higher health care utilisation, lower quality of life and poorer asthma control, the impact of asthma comorbidities on hospitalisation for asthma exacerbation (H-AX) remains less recognised. We aim to analyse the impact of asthma comorbidities on H-AX. Methods Based on a national survey on asthma control and disease perception (CARN 2015 study), we analysed the impact of comorbidities on annual incidence and frequency of H-AX in China. Information on demographic characteristics, asthma comorbidities and annual incidence and frequency of H-AX were presented in this study. Results Among 3875 ambulatory asthma patients, 75.9% (2941/3875) had comorbidities, and 26.4% (1017/3858) experienced H-AX during past year. After adjusting for confounding factors such as demographic data, smoking status and asthma control, COPD [OR = 2.189, 95% CI (1.673, 2.863)] and coronary heart disease [OR = 1.387, 95% CI (1.032, 1.864)] were associated with higher annual incidence, while allergic rhinitis [OR = 0.692, 95% CI (0.588, 0.815)] was associated with lower annual incidence, of H-AX. In terms of frequency, allergic rhinitis [OR = 1.630, 95% CI (1.214, 2.187)], COPD [OR = 1.472, 95% CI (1.021, 2.122)] and anxiety [OR = 2.609, 95% CI (1.051, 6.477)] showed statistically significant correlation with frequent H-AX. Conclusions COPD and coronary heart disease were associated with higher annual incidence, while allergic rhinitis was associated with lower annual incidence of H-AX. Allergic rhinitis, COPD and anxiety were associated with frequent H-AX. Comorbidities may have an important role in the risk and frequency of annual hospitalisations due to asthma exacerbation. The goal of asthma control should rely on a multi-disciplinary treatment protocol.

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